The answer is no...without modification. I have in front of me a 1/10 axle, a 1/6 axle a 1/10 rim and tire and a 1/6 rim and tire.
The rim on the 1/6 is held on to the metal "axle-shaft", which is NOT a "hex", by a Steel Nut with nylon lockthreads. The axle-shaft is sort of shaped like this : 0 a cricle with squared off sides as to apply pressure to the rim, which has a correspondingly shaped hole. This hole is going to be the weak spot on the 1/6, in my humble opinion. The shape only needs a little extra torque to spin them into circles. Im sure some epoxy and a hex shaped reciever of the same size would allow the 1/10 hex axleshaft to fit on the 1/6 rim.
On the reverse side, the 1/10 rim on the 1/6 axleshaft doesnt look like it will work either for the same reason. I'm sure a similar solution would work with this configuration, but why would you want to?
If anyone wants pictures of any of these i will post them on request.
1/10 NB TJ, Aluminum Flapding shocks, Fenders cut, Texacto cut tires, 19160 Jameco Motors, waiting for gears 1/6 NB TJ, FD Style shocks, Custom Paint, Full Lights, Full Hobby Grade Swap Complete